Tew, Garry ORCID: https://orcid.org/0000-0002-8610-0613, Leighton, Dean, Carpenter, Roger, Anderson, Simon, Langmead, Louise, Ramage, John, Faulkner, James, Coleman, Elizabeth, Fairhurst, Caroline, Seed, Michael and Bottoms, Lindsay (2019) High-intensity interval training and moderate-intensity continuous training in adults with Crohn’s disease: a pilot randomised controlled trial. BMC Gastroenterology, 19 (1).

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Abstract

Background: This study assessed the feasibility and acceptability of two common types of exercise training—highintensity interval training (HIIT) and moderate-intensity continuous training (MICT)—in adults with Crohn’s disease (CD).
Methods: In this mixed-methods pilot trial, participants with quiescent or mildly-active CD were randomly assigned 1:
1:1 to HIIT, MICT or usual care control, and followed up for 6 months. The HIIT and MICT groups were offered three
exercise sessions per week for the first 12 weeks. Feasibility outcomes included rates of recruitment, retention, outcome
completion, and exercise attendance. Data were collected on cardiorespiratory fitness (e.g., peak oxygen uptake),
disease activity, fatigue, quality of life, adverse events, and intervention acceptability (via interviews).
Results: Over 17 months, 53 patients were assessed for eligibility and 36 (68%) were randomised (47% male; mean age
36.9 [SD 11.2] years); 13 to HIIT, 12 to MICT, and 11 to control. The exercise session attendance rate was 62% for HIIT
(288/465) and 75% for MICT (320/429), with 62% of HIIT participants (8/13) and 67% of MICT participants (8/12)
completing at least 24 of 36 sessions. One participant was lost to follow-up. Outcome completion rates ranged from 89
to 97%. The mean increase in peak oxygen uptake, relative to control, was greater following HIIT than MICT (2.4 vs. 0.7
mL/kg/min). There were three non-serious exercise-related adverse events, and two exercise participants experienced
disease relapse during follow-up.
Conclusions: The findings support the feasibility and acceptability of the exercise programmes and trial procedures. A
definitive trial is warranted. Physical exercise remains a potentially useful adjunct therapy in CD. [ID: ISRCTN13021107].
Keywords: Inflammatory bowel disease, Exercise therapy, Randomised controlled trial

Item Type:	Article
Status:	Published
DOI:	https://doi.org/10.1186/s12876-019-0936-x
School/Department:	School of Science, Technology and Health
URI:	https://ray.yorksj.ac.uk/id/eprint/6757

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