Hodgson, Philip, Jordan, Alastair ORCID: https://orcid.org/0000-0002-7669-4753, Sinani, Charikleia ORCID: https://orcid.org/0000-0001-8942-8780, Charura, Divine ORCID: https://orcid.org/0000-0002-3509-9392 and Orange, Sam (2023) The relationship between physical function and psychological symptoms in Parkinson’s Disease. A Systematic review and meta-analysis. CNS, Neuroscience and Therapeutics. CNS, Neuroscience and Therapeutics.

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Abstract

Aims: This systematic review and meta-regression analysis aimed to examine available literature reporting measures of physical function, anxiety and/or depression and whether any relationships exist between these measures in individuals with Parkinson’s Disease.

Methods: MEDLINE, CINAHL, AMED, and APA PsychInfo databases were systematically searched. Screening, quality assessment, and data extraction were completed alongside meta-regression analysis.

Results: Of 1,175 studies retrieved, 40 were selected for analysis with only one study assessing the relationship between physical and psychological outcomes within their cohort. 27 studies were also eligible for meta-regression analysis - a total sample of 1,211 participants. Meta-regression analysis of 5 combinations of paired physical and psychological outcomes showed a significant moderating effect of symptoms of depression (Beck Depression Index) on mobility (Timed-Up-and-Go Test) (Coefficient = 0.3675, 95% CI 0.0901 to 0.6450, P = 0.0123) and balance (Berg Balance Score) scores (Coefficient = -1.2518, 95% CI -1.7687 to -0.7349, P = 0.0002).

Conclusion: Although physical and psychological outcomes of interest were used in all included studies, only one examined their relationship. Our analysis suggests that symptoms of depression may influence measures of mobility and balance. Specifically, as the severity of symptoms of depression increase, performance on measures of mobility and balance worsen.

Keywords: Parkinson’s Disease, Systematic Review, Meta-Regression, Physical, Psychological, Symptom Interaction

Item Type:	Article
Status:	Published
DOI:	https://doi.org/10.1111/cns.14562
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM695 Physical therapy. Occupational therapy R Medicine > RZ Other systems of medicine
School/Department:	School of Science, Technology and Health
URI:	https://ray.yorksj.ac.uk/id/eprint/9251

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