Schaefer, Gerald, Doshi, Niraj P., Zhu, Shao Ying and Hu, Qinghua (2014) Analysis of HEp-2 images using MD-LBP and MAD-bagging. In: 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, pp. 4248-4251

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Abstract

Indirect immunofluorescence imaging is employed to identify antinuclear antibodies in HEp-2 cells which founds the basis for diagnosing autoimmune diseases and other important pathological conditions involving the immune system. Six categories of HEp-2 cells are generally considered, namely homogeneous, fine speckled, coarse speckled, nucleolar, cyto-plasmic, and centromere cells. Typically, this categorisation is performed manually by an expert and is hence both time consuming and subjective. In this paper, we present a method for automatically classifiying HEp-2 cells using texture information in conjunction with a suitable classification system. In particular, we extract multidimensional local binary pattern (MD-LBP) texture features to characterise the cell area. These then form the input for a classification stage, for which we employ a margin distribution based bagging pruning (MAD-Bagging) classifier ensemble. We evaluate our algorithm on the ICPR 2012 HEp-2 contest benchmark dataset, and demonstrate it to give excellent performance, superior to all algorithms that were entered in the competition.

Item Type:	Book Section
Status:	Published
DOI:	https://doi.org/10.1109/EMBC.2014.6944562
School/Department:	School of Science, Technology and Health
URI:	https://ray.yorksj.ac.uk/id/eprint/9970

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