Kandola, Aaron, Ashdown-Franks, Garcia ORCID: https://orcid.org/0000-0002-5032-0171, Hendrikse, Joshua, Sabiston, Catherine M and Stubbs, Brendon (2019) Physical activity and depression: Towards understanding the antidepressant mechanisms of physical activity. Neuroscience and biobehavioral reviews, 107. pp. 525-539.

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Abstract

Physical activity can treat and prevent depressive symptoms, but its antidepressant mechanisms are yet to be established. In this review, we comprehensively assess key biological and psychosocial mechanisms through which physical activity exerts antidepressant effects, with a particular focus on exercise. Exercise, a subset of physical activity, influences a range of biological and psychosocial processes also implicated in the pathophysiology of depression. We focus on the capacity for exercise to elicit changes in neuroplasticity, inflammation, oxidative stress, the endocrine system, self-esteem, social support and self-efficacy. We also discuss how a better understanding of these mechanisms can inform the way we design and implement exercise-based interventions to maximise their antidepressant effects on an individual basis. We conclude by presenting a conceptual framework of the key biological and psychosocial mechanisms underlying the relationship between physical activity and depressive symptoms, and the moderators and confounders that may influence it.

Item Type:	Article
Status:	Published
DOI:	10.1016/j.neubiorev.2019.09.040
Subjects:	R Medicine > RA Public aspects of medicine > RA790 Mental health
Institutes:	Institute for Health and Care Improvement
URI:	https://ray.yorksj.ac.uk/id/eprint/10754

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