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Regular walking breaks prevent the decline in cerebral blood flow associated with prolonged sitting

Carter, Sophie, Draijer, Richard, Holder, Sophie, Brown, Louise, Thijssen, Dick H.J. and Hopkins, Nicola (2018) Regular walking breaks prevent the decline in cerebral blood flow associated with prolonged sitting. Journal of Applied Physiology, 125 (3). pp. 790-798.

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Abstract

Decreased cerebrovascular blood flow and function are associated with lower cognitive functioning and increased risk of neurodegenerative diseases. Prolonged sitting impairs peripheral blood flow and function, but its effects on the cerebrovasculature are unknown. This study explored the effect of uninterrupted sitting and breaking up sitting time on cerebrovascular blood flow and function of healthy desk workers. Fifteen participants (10 male, 35.8±10.2 years, BMI: 25.5±3.2 kg∙m-2) completed, on separate days, three 4-hr conditions in a randomised order: a) uninterrupted sitting (SIT), b) sitting with 2-min light intensity walking breaks every 30-min (2WALK) or c) sitting with 8-min light intensity walking breaks every 2-hrs (8WALK). At baseline and 4-hrs, middle cerebral artery blood flow velocity (MCAv), carbon dioxide reactivity (CVR) of the MCA and carotid artery were measured using transcranial Doppler (TCD) and duplex ultrasound respectively. Cerebral autoregulation (CA) was assessed with TCD using a squat-stand protocol and analysed to generate values of gain and phase in the very low, low, and high frequencies. There was a significant decline in SIT MCAv (-3.2±1.2 cm.s-1) compared to 2WALK (0.6±1.5 cm.s-1, p=0.02), but not between SIT and 8WALK (-1.2±1.0 cm.s-1, p=0.14). For CA, the change in 2WALK very low frequency phase (4.47±4.07 degrees) was significantly greater than SIT (-3.38±2.82 degrees, p=0.02). There was no significant change in MCA or carotid artery CVR (p>0.05). Results indicate that prolonged, uninterrupted sitting in healthy desk workers reduces cerebral blood flow, however this is offset when frequent, short-duration walking breaks are incorporated.

Item Type: Article
Status: Published
DOI: https://doi.org/10.1152/japplphysiol.00310.2018
Subjects: Q Science > QP Physiology
School/Department: School of Sport
URI: http://ray.yorksj.ac.uk/id/eprint/3425

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