Hughes, Thomas

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Contact

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Name:

Hughes, Thomas

Email:

t.hughes@yorksj.ac.uk

Department:

School of Science, Technology and Health

Organisation:

York St John University

Address:

Lord Mayor's Walk, York, YO31 7EX

Country:

Biography

Expertise:

cancer, nano medicine, molecular pathology, gene regulation, cell signalling

Job title:

Professor in Bioscience

Biography:

The aim of my research is to increase understanding of the biology of cancers, particularly breast cancer, with a view to using these new insights to improve cancer outcomes.

Qualifications:

BA, DPhil, FHEA

My Latest

Al Amri, Waleed, Al-Amri, Ahmed, Al Abri, Aisha, Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386 and Al Lawati, Fatma (2024) BRCA1/2 Mutations and Outcomes Among Middle Eastern Patients with Early-Onset Breast Cancer in Oman. The Oncologist, 29 (12). e1714-e1722.
Tanner, Georgette, Barrow, Rhiannon, Ajaib, Shoaib, Al-Jabri, Muna, Ahmed, Nazia, Pollock, Steven, Finetti, Martina, Rippaus, Nora, Bruns, Alexander, Syed, Khaja, Poulter, James, Matthews, Laura, Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386, Wilson, Erica, Johnson, Colin, Varn, Frederick, Brüning-Richardson, Anke, Hogg, Catherine, Droop, Alastair, Gusnanto, Arief, Care, Matthew, Cutillo, Luisa, Westhead, David, Susan, Short, Jenkinson, Michael, Brodbelt, Andrew, Chakrabarty, Aruna, Ismail, Azzam, Verhaak, Roel GW and Stead, Lucy F (2024) IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy. Genome Biology, 25 (1).
Khaled, KS, Khot, MI, Aiyappa-Maudsley, R, Maisey, T, Pramanik, A, Tiernan, J, Lintern, N, Al-Enezi, E, Shamsuddin, SH, Tomlinson, D, Coletta, L, Millner, PA, Hughes, TA ORCID: https://orcid.org/0000-0003-1169-3386 and Jayne, DG (2023) Photoactive imaging and therapy for colorectal cancer using a CEA-Affimer conjugated Foslip nanoparticle. Nanoscale, 16. pp. 7185-7199.
Bose, Rahul, Bhattacharya, Ekta, Pramanik, Arindam, Hughes, Thomas A. ORCID: https://orcid.org/0000-0003-1169-3386 and Biswas, Suparna Mandal (2021) Potential oil resources from underutilized seeds of Sterculia foetida, L. - Quality assessment and chemical profiling with other edible vegetable oils based on fatty acid composition, oxidative stability, antioxidant activity and cytotoxicity. Biocatalysis and Agricultural Biotechnology, 33 (102002).
Armstrong, Gemma R., Khot, Mohammed I., Portal, Christophe, West, Nick P., Perry, Sarah L., Maisey, Tom I., Tiernan, Jim P., Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386, Tolan, Damian J. and Jayne, David G. (2022) A novel fluorescent c-met targeted imaging agent for intra-operative colonic tumour mapping: Translation from the laboratory into a clinical trial. Surgical Oncology, 40 (101679).
Websdale, Alex, Kiew, Yi, Chalmers, Philip, Chen, Xinyu, Cioccoloni, Giorgia, Hughes, Thomas A. ORCID: https://orcid.org/0000-0003-1169-3386, Luo, Xinyu, Mwarzi, Rufaro, Poirot, Marc, Røberg-Larsen, Hanne, Wu, Ruoying, Xu, Mengfan, Zulyniak, Michael A. and Thorne, James L. (2022) Pharmacologic and genetic inhibition of cholesterol esterification enzymes reduces tumour burden: a systematic review and meta-analysis of preclinical models. Biochemical pharmacology, 196 (11473).
Lianto, Priscilia, Hutchinson, Samantha A., Moore, Bernadette, Hughes, Thomas A. ORCID: https://orcid.org/0000-0003-1169-3386 and horne, James L. (2021) Characterisation and prognostic value of LXR splice variants in triple negative breast cancer. iScience, 24 (10). p. 103212.
Stevens, William, Farrow, Isabelle M, Georgiou, Leonidas, Hanby, Andrew M, Perren, Timothy J, Windel, Laura M, Wilson, Daniel J, Sharma, Nisha, Dodwell, David, Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386, Dall, Barbara JG and Buckley, David L (2021) Breast tumour volume and blood flow measured by MRI after one cycle of epirubicin and cyclophosphamide-based neoadjuvant chemotherapy as predictors of pathological response. The British Journal of Radiology, 94 (1123).
Lakshmi, Sreerenjini, Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386 and Priya, Sulochana (2021) Exosomes and exosomal RNAs in breast cancer: A status update. European Journal of Cancer (144). pp. 252-268.
Gwili, Noha, Jones, Stacey J., Al Amri, Waleed, Carr, Ian M., Harris, Sarah, Hogan, Brian V., Hughes, William E., Kim, Baek, Langlands, Fiona E., Millican-Slater, Rebecca A., Pramanik, Arindam, Thorne, James L., Verghese, Eldo T., Wells, Geoff, Hamza, Mervat, Younis, Layla, El Deeb, Nevine M. F. and Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386 (2021) Transcriptome profiles of stem-like cells from primary breast cancers allow identification of ITGA7 as a predictive marker of chemotherapy response. British journal of cancer, 125. pp. 983-993.

My Most Viewed

#	Item title
1	Photoactive imaging and therapy for colorectal cancer using a CEA-Affimer conjugated Foslip nanoparticle	119	26
2	BRCA1/2 Mutations and Outcomes Among Middle Eastern Patients with Early-Onset Breast Cancer in Oman	84	20
3	Semaphorins and Their Roles in Breast Cancer: Implications for Therapy Resistance	63	81
4	Characterisation and prognostic value of LXR splice variants in triple negative breast cancer	60	13
5	Potential oil resources from underutilized seeds of Sterculia foetida, L. - Quality assessment and chemical profiling with other edible vegetable oils based on fatty acid composition, oxidative stability, antioxidant activity and cytotoxicity	55	34
6	Potent nutraceuticals having antioxidant, DNA damage protecting potential and anti-cancer properties from the leaves of four Ficus species	54	1
7	IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy	48	19
8	Hyaluronic-Acid-Tagged Cubosomes Deliver Cytotoxics Specifically to CD44-Positive Cancer Cells	47	12
9	Transcriptome profiles of stem-like cells from primary breast cancers allow identification of ITGA7 as a predictive marker of chemotherapy response.	46	20
10	Pharmacologic and genetic inhibition of cholesterol esterification enzymes reduces tumour burden: a systematic review and meta-analysis of preclinical models.	45	1