Hughes, Thomas

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Contact

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Name:

Hughes, Thomas

Email:

t.hughes@yorksj.ac.uk

Department:

School of Science, Technology and Health

Organisation:

York St John University

Address:

Lord Mayor's Walk, York, YO31 7EX

Country:

Biography

Expertise:

cancer, nano medicine, molecular pathology, gene regulation, cell signalling

Job title:

Professor of Bioscience

Biography:

I am an academic cancer biologist with an extensive record of leading research in biomedicine, focusing on the molecular biology of cancers. I have published over 80 peer-reviewed articles and my group has held more than £4M of research funding. I am a highly-experienced reviewer, editor, and panel-member for grant/paper review. I have also acted widely within and outside the UK as an external examiner for taught courses and doctoral degrees. I regularly communicate my work to a variety of scientific and lay audiences through seminars and public lecturers.

Qualifications:

BA, DPhil, FHEA, UKCGE Recognised Research Supervisor

My Latest

Morgan, Jenna L, Hubbard, Thomas, Herbert, Esther, Hartup, Sue, Cheng, Vinton, Barry, Peter A, Copson, Ellen, Cutress, Ramsey I, Dave, Rajiv, Elsberger, Beatrix, Fairbrother, Patricia, Hogan, Brian, Horgan, Kieran, Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386, Kirwan, Cliona C, Mannu, Gurdeep, McIntosh, Stuart A, O’Connel, Rachel L, Patani, Neill, Potter, Shelley, Rattay, Tim, Sheehan, Lisa, Wyld, Lynda and Kim, Baek (2026) National United Kingdom study of the management of breast cancer locoregional recurrence (MARECA) study: Analysis of disease presentation and patient management. European Journal of Surgical Oncology. (In Press)
Pramanik, Arindam, Booth, Andrew, Kobza, Dagmara, Brackenbury, William J, Connell, Simon D, Beales, Paul A and Hughes, Thomas ORCID: https://orcid.org/0000-0003-1169-3386 (2026) EGFR-targeted and MMP-activated membranolytic peptides kill cancer cells specifically in vitro and reduce tumour growth in vivo. Molecular Pharmaceutics, 23 (5). pp. 2955-2964.
Websdale, Alex, Al-Hilali, Yusur, Kim, Baek, Williams, Bethany, Wastall, Laura, Roberg-Larsen, Hanne, Hughes, Thomas ORCID: https://orcid.org/0000-0003-1169-3386, Cioccoloni, Giorgia and Thorne, James L. (2025) Adipocytes in tumour microenvironment promote chemoresistance in triple negative breast 3 cancer through oxysterols. Redox Experimental Medicine, 1 (e2500).
Madigan, Daniel ORCID: https://orcid.org/0000-0002-9937-1818, Hill, Andrew P. ORCID: https://orcid.org/0000-0001-6370-8901, Charura, Divine ORCID: https://orcid.org/0000-0002-3509-9392, Hughes, Thomas ORCID: https://orcid.org/0000-0003-1169-3386 and Baxter, Vanessa ORCID: https://orcid.org/0000-0001-8130-5487 (2025) Cancer awareness and presentation in Humber and North Yorkshire - Findings from 2024/25 Cancer Awareness Measure survey. Project Report. Cancer Alliance. (Unpublished)
Al Amri, Waleel, Al Jabri, Muna, Al Abri, Aisha and Hughes, Thomas ORCID: https://orcid.org/0000-0003-1169-3386 (2025) Cancer Genetics in the Arab World. Technology in Cancer Research & Treatment.
Al Amri, Waleed, Al-Amri, Ahmed, Al Abri, Aisha, Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386 and Al Lawati, Fatma (2024) BRCA1/2 Mutations and Outcomes Among Middle Eastern Patients with Early-Onset Breast Cancer in Oman. The Oncologist, 29 (12). e1714-e1722.
Tanner, Georgette, Barrow, Rhiannon, Ajaib, Shoaib, Al-Jabri, Muna, Ahmed, Nazia, Pollock, Steven, Finetti, Martina, Rippaus, Nora, Bruns, Alexander, Syed, Khaja, Poulter, James, Matthews, Laura, Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386, Wilson, Erica, Johnson, Colin, Varn, Frederick, Brüning-Richardson, Anke, Hogg, Catherine, Droop, Alastair, Gusnanto, Arief, Care, Matthew, Cutillo, Luisa, Westhead, David, Susan, Short, Jenkinson, Michael, Brodbelt, Andrew, Chakrabarty, Aruna, Ismail, Azzam, Verhaak, Roel GW and Stead, Lucy F (2024) IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy. Genome Biology, 25 (1).
Khaled, KS, Khot, MI, Aiyappa-Maudsley, R, Maisey, T, Pramanik, A, Tiernan, J, Lintern, N, Al-Enezi, E, Shamsuddin, SH, Tomlinson, D, Coletta, L, Millner, PA, Hughes, TA ORCID: https://orcid.org/0000-0003-1169-3386 and Jayne, DG (2023) Photoactive imaging and therapy for colorectal cancer using a CEA-Affimer conjugated Foslip nanoparticle. Nanoscale, 16. pp. 7185-7199.
Bose, Rahul, Bhattacharya, Ekta, Pramanik, Arindam, Hughes, Thomas A. ORCID: https://orcid.org/0000-0003-1169-3386 and Biswas, Suparna Mandal (2021) Potential oil resources from underutilized seeds of Sterculia foetida, L. - Quality assessment and chemical profiling with other edible vegetable oils based on fatty acid composition, oxidative stability, antioxidant activity and cytotoxicity. Biocatalysis and Agricultural Biotechnology, 33 (102002).
Armstrong, Gemma R., Khot, Mohammed I., Portal, Christophe, West, Nick P., Perry, Sarah L., Maisey, Tom I., Tiernan, Jim P., Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386, Tolan, Damian J. and Jayne, David G. (2022) A novel fluorescent c-met targeted imaging agent for intra-operative colonic tumour mapping: Translation from the laboratory into a clinical trial. Surgical Oncology, 40 (101679).

My Most Viewed

#	Item title
1	Photoactive imaging and therapy for colorectal cancer using a CEA-Affimer conjugated Foslip nanoparticle	225	47
2	Hyaluronic-Acid-Tagged Cubosomes Deliver Cytotoxics Specifically to CD44-Positive Cancer Cells	196	43
3	BRCA1/2 Mutations and Outcomes Among Middle Eastern Patients with Early-Onset Breast Cancer in Oman	194	39
4	Characterisation and prognostic value of LXR splice variants in triple negative breast cancer	178	31
5	IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy	160	52
6	Transcriptome profiles of stem-like cells from primary breast cancers allow identification of ITGA7 as a predictive marker of chemotherapy response.	160	51
7	Pharmacologic and genetic inhibition of cholesterol esterification enzymes reduces tumour burden: a systematic review and meta-analysis of preclinical models.	159	1
8	Semaphorins and Their Roles in Breast Cancer: Implications for Therapy Resistance	155	123
9	Potent nutraceuticals having antioxidant, DNA damage protecting potential and anti-cancer properties from the leaves of four Ficus species	154	1
10	Potential oil resources from underutilized seeds of Sterculia foetida, L. - Quality assessment and chemical profiling with other edible vegetable oils based on fatty acid composition, oxidative stability, antioxidant activity and cytotoxicity	149	91