Winfield, Zach and Perry, Matt (2025) Should Balanced Crystalloids be used in the Prehospital Setting to Treat Adult Sepsis Patients? A Systematic Literature Review. Journal of Paramedic Practice. (In Press)

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Abstract

Background

Current UK practice leaves paramedics unable to administer balanced crystalloid fluid for early treatment of sepsis, something that the UK National Institute for Health and Care Excellence suggest has value.

Aims

This research examines the current literature to identify a case for change to include improved prehospital sepsis care. This research considered: Are balanced crystalloids more effective at treating sepsis, and should they be implemented into paramedic practice?

Methods
This research was conducted using a systematic review process. A thematic analysis was completed to produce narrative themes.
Findings
Four themes were identified within the literature that generally describe an improved patient outcome through the early use of balanced crystalloids in sepsis.

Conclusion

Balanced crystalloids offer advantages over normal saline for treating sepsis, including reducing the rates of electrolyte abnormalities and improving renal function. Balanced crystalloids are preferable to normal saline when treating adults with sepsis in the prehospital setting.

Item Type:	Article
Status:	In Press
Subjects:	R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica R Medicine > RZ Other systems of medicine
School/Department:	School of Science, Technology and Health
URI:	https://ray.yorksj.ac.uk/id/eprint/11364

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