Otto, J. M., O'Doherty, Alasdair Fraser ORCID: https://orcid.org/0000-0002-9953-9772, Hennis, P. J., Mitchell, K., Pate, J. S., Cooper, J. A., Grocott, M. P. W. and Montgomery, H. E. (2012) Preoperative exercise capacity in adult inflammatory bowel disease sufferers, determined by cardiopulmonary exercise testing. International Journal of Colorectal Disease, 27 (11). pp. 1485-1491.

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Abstract

Background and aims
Aerobic exercise capacity appears impaired in children with inflammatory bowel disease (IBD). Whether this holds true in adults with IBD is not known. Using cardiopulmonary exercise testing (CPET), we assessed anaerobic threshold (AT) in such patients comparing data with reference values and other elective surgical patients. We also sought to confirm whether the presence of a fistula further reduced AT.

Methods
CPET was performed between November 2007 and December 2010 on patients awaiting abdominopelvic surgery. Gender-specific normal reference values were used for comparison. Unadjusted comparison between two groups was made using Mann–Whitney U test and by unpaired t test. Data were adjusted by analysis of covariance, using age and sex as covariates. Differences between patients’ observed values and reference values were tested using paired t tests.

Results
Four hundred and fourteen patients (234 male) were studied (mean ± SD age, 56.6 ± 16.4 years; weight, 74.2 ± 15.6 kg). Adjusted AT values in Crohn’s disease (CD) were lower than colorectal cancer (11.4 ± 3.4 vs 13.2 ± 3.5 ml.kg−1.min−1, p = 0.03) and for all other colorectal disease groups combined (12.6 ± 3.5 ml.kg−1.min−1, p = 0.03). AT of Ulcerative colitis (UC) and CD patients together were reduced compared to population reference values (p < 0.05).

Conclusion
After adjusting for age and sex, CD patients had a reduced AT compared to patients with colorectal cancer and other colorectal disease groups combined. The pathogenesis of this low AT remains to be defined and warrants further investigation.

Item Type:	Article
Status:	Published
DOI:	10.1007/s00384-012-1533-4
School/Department:	School of Science, Technology and Health
Institutes:	Institute for Health and Care Improvement
URI:	https://ray.yorksj.ac.uk/id/eprint/15464

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