Otto, James M, O'Doherty, Alasdair Fraser ORCID: https://orcid.org/0000-0002-9953-9772, Hennis, Philip J, Cooper, Jackie A, Grocott, Michael Pw, Snowdon, Chris, Carlisle, John B, Swart, Michael, Richards, Toby and Montgomery, Hugh E (2013) Association between preoperative haemoglobin concentration and cardiopulmonary exercise variables: a multicentre study. Perioperative Medicine, 2 (1). p. 18.

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Abstract

Background: Preoperative anaemia and low exertional oxygen uptake are both associated with greater postoperative morbidity and mortality. This study reports the association among haemoglobin concentration ([Hb]),peak oxygen uptake (V_O2 peak) and anaerobic threshold (AT) in elective surgical patients.
Methods: Between 1999 and 2011, preoperative [Hb] and cardiopulmonary exercise tests were recorded in 1,777 preoperative patients in four hospitals. The associations between [Hb], V_O2 peak and AT were analysed by linear regression and covariance.
Results: In 436 (24.5%) patients, [Hb] was <12 g dl-1 and, in 83 of these, <10 g dl-1. Both AT and V_O2 peak rose
modestly with increasing [Hb] (r2 = 0.24, P <0.0001 and r2 = 0.30, P <0.0001, respectively). After covariate adjustment, an increase in [Hb] of one standard deviation was associated with a 6.7 to 9.7% increase in V_O2 peak, and a rise of 4.4 to 6.0% in AT. Haemoglobin concentration accounted for 9% and 6% of the variation in V_O2 peak and AT respectively.
Conclusions: To a modest extent, lower haemoglobin concentrations are independently associated with lower
oxygen uptake during preoperative cardiopulmonary exercise testing. It is unknown whether this association is
causative.
Keywords: Anaemia, Cardiopulmonary exercise testing, CPET, Haemoglobin concentration, Oxygen uptake, Surgery

Item Type:	Article
Status:	Published
DOI:	10.1186/2047-0525-2-18
School/Department:	School of Science, Technology and Health
Institutes:	Institute for Health and Care Improvement
URI:	https://ray.yorksj.ac.uk/id/eprint/15462

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