Prof Thomas A Hughes

• Professor in Bioscience
• School of Science, Technology and Health

Link to Public Profile

Article

Tanner, Georgette, Barrow, Rhiannon, Ajaib, Shoaib, Al-Jabri, Muna, Ahmed, Nazia, Pollock, Steven, Finetti, Martina, Rippaus, Nora, Bruns, Alexander, Syed, Khaja, Poulter, James, Matthews, Laura, Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386, Wilson, Erica, Johnson, Colin, Varn, Frederick, Brüning-Richardson, Anke, Hogg, Catherine, Droop, Alastair, Gusnanto, Arief, Care, Matthew, Cutillo, Luisa, Westhead, David, Susan, Short, Jenkinson, Michael, Brodbelt, Andrew, Chakrabarty, Aruna, Ismail, Azzam, Verhaak, Roel GW and Stead, Lucy F (2024) IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy. Genome Biology, 25 (1).

Khaled, KS, Khot, MI, Aiyappa-Maudsley, R, Maisey, T, Pramanik, A, Tiernan, J, Lintern, N, Al-Enezi, E, Shamsuddin, SH, Tomlinson, D, Coletta, L, Millner, PA, Hughes, TA ORCID: https://orcid.org/0000-0003-1169-3386 and Jayne, DG (2023) Photoactive imaging and therapy for colorectal cancer using a CEA-Affimer conjugated Foslip nanoparticle. Nanoscale.

Radhika Aiyappa, Radhika ORCID: https://orcid.org/0000-0003-4900-4013, McLoughlin, Louis FV and Hughes, Thomas A. ORCID: https://orcid.org/0000-0003-1169-3386 (2023) Semaphorins and Their Roles in Breast Cancer: Implications for Therapy Resistance. International Journal of Molecular Sciences, 24 (17).

Dutta, Rajashree, Bhattacharya, Ekta, Pramanik, Arindam, Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386 and Biswas, Suparna Mandal (2022) Potent nutraceuticals having antioxidant, DNA damage protecting potential and anti-cancer properties from the leaves of four Ficus species. Biocatalysis and Agricultural Biotechnology, 44 (102461).

Pramanik, Arindam, Xu, Zexi, Ingram, Nicola, Coletta, Patricia Louise, Millner, Paul A., Tyler, Arwen I I and Hughes, Thomas A. ORCID: https://orcid.org/0000-0003-1169-3386 (2022) Hyaluronic-Acid-Tagged Cubosomes Deliver Cytotoxics Specifically to CD44-Positive Cancer Cells. Molecular Pharmaceutics.

Armstrong, Gemma R., Khot, Mohammed I., Portal, Christophe, West, Nick P., Perry, Sarah L., Maisey, Tom I., Tiernan, Jim P., Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386, Tolan, Damian J. and Jayne, David G. (2022) A novel fluorescent c-met targeted imaging agent for intra-operative colonic tumour mapping: Translation from the laboratory into a clinical trial. Surgical Oncology, 40 (101679).

Pramanik, Arindam, Xu, Zexi, Shamsuddin, Shazana H., Khaled, Yazan S., Ingram, Nicola, Maisey, Thomas, Tomlinson, Darren, Coletta, P. Louise, Jayne, David, Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386, Tyler, Arwen I. I. and Millner, Paul A. (2022) Affimer Tagged Cubosomes: Targeting of Carcinoembryonic Antigen Expressing Colorectal Cancer Cells Using In Vitro and In Vivo Models. ACS applied materials & interfaces, 14 (9). pp. 11078-11091.

Websdale, Alex, Kiew, Yi, Chalmers, Philip, Chen, Xinyu, Cioccoloni, Giorgia, Hughes, Thomas A. ORCID: https://orcid.org/0000-0003-1169-3386, Luo, Xinyu, Mwarzi, Rufaro, Poirot, Marc, Røberg-Larsen, Hanne, Wu, Ruoying, Xu, Mengfan, Zulyniak, Michael A. and Thorne, James L. (2022) Pharmacologic and genetic inhibition of cholesterol esterification enzymes reduces tumour burden: a systematic review and meta-analysis of preclinical models. Biochemical pharmacology, 196 (11473).

Baxter, Diana E., Allinson, Lisa M., Al Amri, Waleed S., Poulter, James A., Pramanik, Arindam, Thorne, James L., Verghese, Eldo T. and Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386 (2021) MiR-195 and Its Target SEMA6D Regulate Chemoresponse in Breast Cancer. Cancers.

Lianto, Priscilia, Hutchinson, Samantha A., Moore, Bernadette, Hughes, Thomas A. ORCID: https://orcid.org/0000-0003-1169-3386 and horne, James L. (2021) Characterisation and prognostic value of LXR splice variants in triple negative breast cancer. iScience, 24 (10). p. 103212.

Gwili, Noha, Jones, Stacey J., Al Amri, Waleed, Carr, Ian M., Harris, Sarah, Hogan, Brian V., Hughes, William E., Kim, Baek, Langlands, Fiona E., Millican-Slater, Rebecca A., Pramanik, Arindam, Thorne, James L., Verghese, Eldo T., Wells, Geoff, Hamza, Mervat, Younis, Layla, El Deeb, Nevine M. F. and Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386 (2021) Transcriptome profiles of stem-like cells from primary breast cancers allow identification of ITGA7 as a predictive marker of chemotherapy response. British journal of cancer, 125. pp. 983-993.

Nienyun Hsu, Sharon, Hui, Erika Wong En, Mengzhen Liu, Mengzhen Liu, Wu, Di, Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386 and Smith, James (2021) Revealing nuclear receptor hub modules from Basal-like breast cancer expression networks. PLOS ONE, 16 (6). e0252901.

Stevens, William, Farrow, Isabelle M, Georgiou, Leonidas, Hanby, Andrew M, Perren, Timothy J, Windel, Laura M, Wilson, Daniel J, Sharma, Nisha, Dodwell, David, Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386, Dall, Barbara JG and Buckley, David L (2021) Breast tumour volume and blood flow measured by MRI after one cycle of epirubicin and cyclophosphamide-based neoadjuvant chemotherapy as predictors of pathological response. The British Journal of Radiology, 94 (1123).

Armstrong, Gemma R., Khot, Mohammed Ibrahim, Tiernan, Jim P., West, Nick P., Perry, Sarah L., Maisey, Tom I., Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386 and Jayne, David G. (2021) The utility of c-Met as a diagnostic tissue biomarker in primary colorectal cancer. International journal of experimental pathology, 102 (3). pp. 172-178.

Bose, Rahul, Bhattacharya, Ekta, Pramanik, Arindam, Hughes, Thomas A. ORCID: https://orcid.org/0000-0003-1169-3386 and Biswas, Suparna Mandal (2021) Potential oil resources from underutilized seeds of Sterculia foetida, L. - Quality assessment and chemical profiling with other edible vegetable oils based on fatty acid composition, oxidative stability, antioxidant activity and cytotoxicity. Biocatalysis and Agricultural Biotechnology, 33 (102002).

Hutchinson, Samantha A., Websdale, Alex, Cioccoloni, Giorgia, Røberg-Larsen, Hanne, Lianto, Priscilia, Kim, Baek, Rose, Ailsa, Soteriou, Chrysa, Pramanik, Arindam, Wastall, Laura M., Williams, Bethany J., Henn,, Madeline A., Chen, Joy J., Ma, Liqian, Moore, J. Bernadette, Nelson, Erik, Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386 and Thorne, James L. (2021) Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer. Oncogene, 40. pp. 2872-2883.

Lakshmi, Sreerenjini, Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386 and Priya, Sulochana (2021) Exosomes and exosomal RNAs in breast cancer: A status update. European Journal of Cancer (144). pp. 252-268.

Broad, Robyn V., Jones, Stacey J., Teske, Melina C., Wastall, Laura M., Hanby, Andrew M., Thorne, James L. and Hughes, Thomas A ORCID: https://orcid.org/0000-0003-1169-3386 (2021) Inhibition of interferon-signalling halts cancer-associated fibroblast-dependent protection of breast cancer cells from chemotherapy. British Journal of Cancer, 124. pp. 1110-1120.